MAGNESIUM

• Magnesium ions (Mg2+) move between the blood vessels and 3 different body compartments:
   Renal tubule: via renal reabsorption and excretion mechanisms
   Gut lumen: via absorption and secretion across GI cells
   Intracellular space: via movement across ion channels
• Mg imbalance arise when their movements between these body compartments are disregulated.

hypomagnesemia


             2 main causes of hypomagnesemia:
             - GI loss
             - Decreased renal reabsorption

mechanism of hypomagnesemia

hypermagnesemia


             2 main causes of hypermagnesemia:
             - GI gain
             - Decreased renal excretion

mechanism of hypomagnesemia
HYPOMAGNESEMIA

✿ Decreased renal reabsorption
  ✧ hypercalcemia
  ✧ diabetes mellitus
  ✧ drugs
    ⁎ diuretics (loops, thiazide)
    ⁎ calcineurin inhibitors
    ⁎ abx (aminoglycoside, amphotericin)
    ⁎ cisplatin
    ⁎ anti-egf receptor ab (cetuximab)
  ✧ alcohol abuse
  ✧ postobstructive diuresis
  ✧ bartter / gitelman syndrome
  ✧ familial hypomagnesemia
  ✧ post acute tubular necrosis
  ✧ post kidney transplant

✿ GI loss
  ✧ secretory diarrhea
  ✧ malabsorption/ steatorrhea
  ✧ small bowel bypass surgery
  ✧ primary intestinal hypomagnesemia
  ✧ drugs
    ⁎ proton pump inhibitors

✿ Other
  ✧ acute pancreatitis
  ✧ hungry bone syndrome
HYPERMAGNESEMIA

✿ Decreased renal excretion        
  ✧ renal insufficiency

✿ Increased gut absorption
  ✧ magnesium oral ingestion
    ⁎ epsom salts
    ⁎ laxatives
  ✧ magnesium enema

✿ Other
  ✧ magnesium iv infusion
  ✧ tumor lysis syndrome

related topics




potassium
calcium
urine chemistry
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