• Cardiac amyloidosis is a condition wherein misfolded proteins are deposited in myocytes causing infiltrative cardiomyopathy.
• There are 5 types of cardiac amyloidosis: ATTRwt, ATTRm, AL, and 2 rarer types, AA and ApoA-1
Transthyretin amyloidosis (ATTR): either wild type (ATTRwt, non-herediraty, "senile") or mutant (ATTRm, hereditary)
Light chain amyloidosis (AL)
Serum amyloid A amyloidosis (AA)
Apoliprotein A-1 amyloidosis (ApoA-1)
• ECG findings associated with cardic amyloidosis include:
Low QRS amplitude but LV hypertrophy on echocardiography
Pseudo-infarct pattern (Q waves in ≥ 2 contiguous leads without obstructive CAD)
LVH or LBBB +/- AV block (common in ATTRwt)
